4-AcO-DET

📅 آخر تحديث: ٣١ يوليو ٢٠٢٦
✍️ نُشر في: ٣١ يوليو ٢٠٢٦
الموسوعة الحرة

4-AcO-DET, also known as 4-acetoxy-N,N-diethyltryptamine as well as ethacetin or ethylacybin, is a psychedelictryptamine.[1][2]

Use and effects

4-AcO-DET is orally active, and doses of 10 to 25 mg are common.[1][2] Effects last 3 to 6 hours.[1][2] The free base is also active when smoked in a dose range of 5 to 20 mg.[2] Smoking 4-AcO-DET greatly speeds up the onset; peak effects are experienced within 10 minutes, and are usually over within 1 hour.[2]

Interactions

Pharmacology

It is expected that 4-AcO-DET is quickly hydrolyzed into the free phenolic 4-HO-DET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.[1][2]

Chemistry

4-AcO-DET is said to be more chemically stable than 4-HO-DET.[2]

Analogues

Analogues of 4-AcO-DET include diethyltryptamine (DET), 4-HO-DET (ethocin), ethocybin (4-PO-DET), 4-AcO-DMT (psilacetin), 4-AcO-DPT, 4-AcO-MET, and 4-AcO-MPT, among others.

History

4-AcO-DET was first synthesized by Albert Hofmann and Franz Troxler at Sandoz in 1958.[2]

Society and culture

Canada

4-AcO-DET is not an explicitly nor implicitly controlled substance in Canada as of 2025.[3]

Finland

Listed in the "government decree on psychoactive substances banned from the consumer market".[4]

Sweden

Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-AcO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-acetoxi-N,N-dietyltryptamin (4-AcO-DET), making it illegal to sell or possess.[5]

United States

4-AcO-DET is not an explicitly controlled substance in the United States.[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

In consumer products

In December of 2025 the California department of public health issued a warning that products being sold as Magic Mushroom gummies chocolate bars and syrups contained 4-Aco-DET alongside 4-Aco-DMT.[7] They advised against consuming these products stating they may cause "severe illness, hospitalization, or even death". Severe adverse reactions such as extreme anxiety and vomiting have been reported from consumer products containing 4-Aco-DET from a variety of different brands.[8]

See also

References

  1. 123456Shulgin A, Shulgin A. "#16. 4-HO-DET". Tikhal: The Chemistry Continues. Retrieved 19 April 2007.
  2. 123456789Toad (2001). "4-Acetoxy-DET Primer". The Entheogen Review. 10 (3): 88–96. ISSN 1066-1913. Archived from the original on 9 June 2026.
  3. ↑"Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
  4. ↑"Valtioneuvoston asetus kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista".
  5. ↑Svensk författningssamling (13 October 2005). "Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor;"(PDF). Archived from the original(PDF) on 4 March 2016. Retrieved October 10, 2015.
  6. ↑Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026)(PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
  7. ↑"CDPH Warns Consumers Not to Eat TRE House Brand Magic Mushroom Gummies, Chocolate Bars, and Syrup". December 11, 2025.
  8. ↑""Mushroom gummies" containing synthetic tryptamines". March 7, 2025.