M320 (opioid)

📅 آخر تحديث: ٣ أغسطس ٢٠٢٦
✍️ نُشر في: ٣ أغسطس ٢٠٢٦
الموسوعة الحرة

M320 is an extremely potent and long acting opioid. It produces long lasting narcosis in different animals, including mice, rats, cats, guinea pigs, dogs and monkeys.[1] M320 is a μ and κ-opioid receptoragonist. Similarly to TL 2636, M320 tends to produce pronounced nausea and vomiting due to its potent agonist activity at both the μ and κ-opioid receptors at the same time.[2][3][4]

See also

References

  1. ↑Boura AL, Fitzgerald AE (February 1966). "The pharmacology of N-(cyclopropylmethyl)-19-isopentylnororvinol hydrochloride. A potent and long lasting central depressant". British Journal of Pharmacology and Chemotherapy. 26 (2): 307–321. doi:10.1111/j.1476-5381.1966.tb01910.x. PMC 1510649. PMID 4958020.
  2. ↑Abrahams JM, Boura AL, Evans RG, Johnston CI, Olley JE (December 1986). "The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol (M320), a potent agonist at kappa- and mu-opiate receptors, on urine excretion of rats". British Journal of Pharmacology. 89 (4): 759–767. doi:10.1111/j.1476-5381.1986.tb11180.x. PMC 1917223. PMID 3028550.
  3. ↑Evans RG, Rice GE, Olley JE (November 1988). "Studies of the effects of subacute treatment with N-(cyclopropylmethyl)-19-isopentylnororvinol (M320) on timing of parturition in the rat". British Journal of Pharmacology. 95 (3): 777–782. doi:10.1111/j.1476-5381.1988.tb11704.x. PMC 1854236. PMID 3207993.
  4. ↑Greedy BM, Bradbury F, Thomas MP, Grivas K, Cami-Kobeci G, Archambeau A, et al. (April 2013). "Orvinols with mixed kappa/mu opioid receptor agonist activity". Journal of Medicinal Chemistry. 56 (8): 3207–3216. doi:10.1021/jm301543e. PMC 3646402. PMID 23438330.